SELECTED PUBLICATIONS

2022

Pla-Prats C, Thomä NH. Quality control of protein complex assembly by the ubiquitin-proteasome system. Trends Cell Biol. 2022 Aug;32(8):696-706. doi: 10.1016/j.tcb.2022.02.005.

2021

Michael AK, Thomä NH. Reading the chromatinized genome. Cell. 2021 Jul 8;184(14):3599-3611. doi: 10.1016/j.cell.2021.05.029.

Kozicka Z, Thomä NH. Haven't got a glue: Protein surface variation for the design of molecular glue degraders. Cell Chem Biol. 2021;28(7):1032-1047. doi:10.1016/j.chembiol.2021.04.009

Mohamed WI, Schenk AD, Kempf G, Cavadini S, Basters A, Potenza A, Rahman WA, Rabl J, Reichermeier K, Thomä NH. The CRL4-DCAF1 cullin-RING ubiquitin ligase is activated following a switch in oligomerization state. EMBO J. 2021 Nov 15;40(22):e108008. doi: 10.15252/embj.2021108008.

2020

Pathare GR, Decout A, Glück S, Cavadini S, Makasheva K, Hovius R, Kempf G, Weiss J, Kozicka Z, Guey B, Melenec P, Fierz B, Thomä NH, Ablasser A. Structural mechanism of cGAS inhibition by the nucleosome. Nature. 2020 Nov;587(7835):668-672. doi: 10.1038/s41586-020-2750-6.

Mayor-Ruiz C, Bauer S, Brand M, Kozicka Z, Siklos M, Imrichova H, Kaltheuner IH, Hahn E, Seiler K,
Koren A, Petzold G, Fellner M, Bock C, Müller AC, Zuber J, Geyer M, Thomä NH, Kubicek S, Winter GE.

Rational discovery of molecular glue degraders via scalable chemical profiling Nat Chem Biol. 2020 Nov;16(11):1199-1207. doi: 10.1038/s41589-020-0594-x.

Kassube SA, Thomä NH. Structural insights into Fe-S protein biogenesis by the CIA targeting complex.

Nat Struct Mol Biol. 2020 Aug;27(8):735-742. doi: 10.1038/s41594-020-0454-0.

Słabicki M, Kozicka Z, Petzold G, Li YD, Manojkumar M, Bunker RD, Donovan KA, Sievers QL, Koeppel J,

Suchyta D, Sperling AS, Fink EC, Gasser JA, Wang LR, Corsello SM, Sellar RS, Jan M, Gillingham D, Scholl C, Fröhling S, Golub TR, Fischer ES, Thomä NH, Ebert BL. The CDK inhibitor CR8 acts as a molecular glue degrader that depletes cyclin K. Nature. 2020 Sep;585(7824):293-297. doi: 10.1038/s41586-020-2374-x.

Michael AK, Grand RS, Isbel L*, Cavadini S, Kozicka Z, Kempf G, Bunker RD, Schenk AD, Graff-Meyer A, Pathare GR, Weiss J, Matsumoto S, Burger L, Schübeler D, Thomä NH. Mechanisms of OCT4-SOX2 motif readout on nucleosomes. Science. 2020 Jun 26;368(6498):1460-1465. doi: 10.1126/science.abb0074.

Schenk AD, Cavadini S, Thomä NH, Genoud C. Live Analysis and Reconstruction of Single-Particle Cryo-Electron Microscopy Data with CryoFLARE J Chem Inf Model. 2020 May 26;60(5):2561-2569.

doi: 10.1021/acs.jcim.9b01102.

Aguirre JD, Thomä NH. FANally…A Structure Emerges of the Fanconi Anemia Core Complex. Trends Biochem Sci. 2020 Apr;45(4):275-276. doi: 10.1016/j.tibs.2020.01.001.

Reichermeier KM, Straube R, Reitsma JM, Sweredoski MJ, Rose CM, Moradian A, den Besten W, Hinkle T, Verschueren E, Petzold G, Thomä NH, Wertz IE, Deshaies RJ, Kirkpatrick DS. PIKES Analysis Reveals Response to Degraders and Key Regulatory Mechanisms of the CRL4 Network. Mol Cell. 2020 Mar 5;77(5):1092-1106.e9. doi: 10.1016/j.molcel.2019.12.013.

Kozicka Z, Petzold G, Thomä NH. Taking the Brakes Off Targeted Protein Degradation. Cell Chem Biol. 2020 Jan 16;27(1):16-18. doi: 10.1016/j.chembiol.2019.12.010.

2019

Matsumoto S, Cavadini S, Bunker RD*, Grand RS, Potenza A, Rabl J, Yamamoto J, Schenk AD, Schübeler D, Iwai S, Sugasawa K, Kurumizaka H & Thomä NH (2019) DNA damage detection in nucleosomes involves DNA register shifting. Nature. Jul;571(7763):79-84.

Rabl J, Bunker RD, Schenk AD, Cavadini S, Gill ME, Abdulrahman W, Andrés-Pons A, Luijsterburg MS, Ibrahim AFM, Branigan E, Aguirre JD, Marceau AH, Guérillon C, Bouwmeester T, Hassiepen U, Peters AHFM, Renatus M, Gelman L, Rubin SM, Mailand N, van Attikum H, Hay RT, Thomä NH. (2019) Structural Basis of BRCC36 Function in DNA Repair and Immune Regulation. Molecular Cell . Aug;75, 1–15

2018

Sievers QL,* Petzold G*, Bunker RD, Renneville A, Slabicki M, Liddicoat BJ, Abdulrahman W, Mikkelsen T, Ebert BL, Thomä NH (2018) Defining the human C2H2 zinc finger degrome targeted by thalidomide analogs through CRBN. Science. Nov 2;362(6414)

Cannavo E, Johnson D, Andres SN, Kissling VM, Reinert JK, Garcia V, Erie DA, Hess D, Thomä NH, Enchev RI, Peter M, Williams RS, Neale MJ, Cejka P (2018) Regulatory control of DNA end resection by Sae2 phosphorylation. Nature Communications. Oct 1;9(1):4016

Fontana GA, Reinert JK, Thomä NH, Rass U. (2018) Shepherding DNA ends: Rif1 protects telomeres and chromosome breaks. Microb Cell. May 17;5(7):327-343

Ostapcuk V, Mohn F, Carl SH, Basters A, Hess D, Iesmantavicius V, Lampersberger L, Flemr M, Pandey A, Thomä NH, Betschinger J, Bühler M. (2018) Activity-dependent neuroprotective protein recruits HP1 and CHD4 to control lineage-specifying genes. Nature. May;557(7707):739-743.

2017

Mattarocci S, Reinert JK, Bunker RD, Fontana GA, Shi T, Klein D, Cavadini S, Faty M, Shyian M, Hafner L, Shore D, Thomä NH, Rass U. (2017) Rif1 maintains telomeres and mediates DNA repair by encasing DNA ends. Nature Structural & Molecular Biology Jul;24(7):588-595

Walczak MJ, Petzold G, Thomä NH (2017) Targeted protein degradation: You can glue it too! Nature Chemical Biology. Apr 13;13(5):452-453.

For full list of publications click here

THOMÄ LAB

THOMÄ LAB

SELECTED PUBLICATIONS

2022

Pla-Prats C, Thomä NH. Quality control of protein complex assembly by the ubiquitin-proteasome system. Trends Cell Biol. 2022 Aug;32(8):696-706. doi: 10.1016/j.tcb.2022.02.005.

2021

Michael AK, Thomä NH. Reading the chromatinized genome. Cell. 2021 Jul 8;184(14):3599-3611. doi: 10.1016/j.cell.2021.05.029.

Kozicka Z, Thomä NH. Haven't got a glue: Protein surface variation for the design of molecular glue degraders. Cell Chem Biol. 2021;28(7):1032-1047. doi:10.1016/j.chembiol.2021.04.009

2020

Pathare GR, Decout A, Glück S, Cavadini S, Makasheva K, Hovius R, Kempf G, Weiss J, Kozicka Z, Guey B, Melenec P, Fierz B, Thomä NH, Ablasser A. Structural mechanism of cGAS inhibition by the nucleosome. Nature. 2020 Nov;587(7835):668-672. doi: 10.1038/s41586-020-2750-6.

Kassube SA, Thomä NH. Structural insights into Fe-S protein biogenesis by the CIA targeting complex.

Nat Struct Mol Biol. 2020 Aug;27(8):735-742. doi: 10.1038/s41594-020-0454-0.

Słabicki M, Kozicka Z, Petzold G, Li YD, Manojkumar M, Bunker RD, Donovan KA, Sievers QL, Koeppel J,

Michael AK, Grand RS, Isbel L*, Cavadini S, Kozicka Z, Kempf G, Bunker RD, Schenk AD, Graff-Meyer A, Pathare GR, Weiss J, Matsumoto S, Burger L, Schübeler D, Thomä NH. Mechanisms of OCT4-SOX2 motif readout on nucleosomes. Science. 2020 Jun 26;368(6498):1460-1465. doi: 10.1126/science.abb0074.

Schenk AD, Cavadini S, Thomä NH, Genoud C. Live Analysis and Reconstruction of Single-Particle Cryo-Electron Microscopy Data with CryoFLARE J Chem Inf Model. 2020 May 26;60(5):2561-2569.

doi: 10.1021/acs.jcim.9b01102.

2019

Matsumoto S, Cavadini S, Bunker RD*, Grand RS, Potenza A, Rabl J, Yamamoto J, Schenk AD, Schübeler D, Iwai S, Sugasawa K, Kurumizaka H & Thomä NH (2019) DNA damage detection in nucleosomes involves DNA register shifting. Nature. Jul;571(7763):79-84.

2018

Sievers QL,* Petzold G*, Bunker RD, Renneville A, Slabicki M, Liddicoat BJ, Abdulrahman W, Mikkelsen T, Ebert BL, Thomä NH (2018) Defining the human C2H2 zinc finger degrome targeted by thalidomide analogs through CRBN. Science. Nov 2;362(6414)

Cannavo E, Johnson D, Andres SN, Kissling VM, Reinert JK, Garcia V, Erie DA, Hess D, Thomä NH, Enchev RI, Peter M, Williams RS, Neale MJ, Cejka P (2018) Regulatory control of DNA end resection by Sae2 phosphorylation. Nature Communications. Oct 1;9(1):4016

Fontana GA, Reinert JK, Thomä NH, Rass U. (2018) Shepherding DNA ends: Rif1 protects telomeres and chromosome breaks. Microb Cell. May 17;5(7):327-343

Ostapcuk V, Mohn F, Carl SH, Basters A, Hess D, Iesmantavicius V, Lampersberger L, Flemr M, Pandey A, Thomä NH, Betschinger J, Bühler M. (2018) Activity-dependent neuroprotective protein recruits HP1 and CHD4 to control lineage-specifying genes. Nature. May;557(7707):739-743.

2017

Mattarocci S, Reinert JK, Bunker RD, Fontana GA, Shi T, Klein D, Cavadini S, Faty M, Shyian M, Hafner L, Shore D, Thomä NH, Rass U. (2017) Rif1 maintains telomeres and mediates DNA repair by encasing DNA ends. Nature Structural & Molecular Biology Jul;24(7):588-595

Walczak MJ, Petzold G, Thomä NH (2017) Targeted protein degradation: You can glue it too! Nature Chemical Biology. Apr 13;13(5):452-453.

For full list of publications click here

@LabThoma

THOMÄ LAB

THOMÄ LAB

SELECTED PUBLICATIONS

2022

Pla-Prats C, Thomä NH. Quality control of protein complex assembly by the ubiquitin-proteasome system. Trends Cell Biol. 2022 Aug;32(8):696-706. doi: 10.1016/j.tcb.2022.02.005.

2021

Michael AK, Thomä NH. Reading the chromatinized genome. Cell. 2021 Jul 8;184(14):3599-3611. doi: 10.1016/j.cell.2021.05.029.

Kozicka Z, Thomä NH. Haven't got a glue: Protein surface variation for the design of molecular glue degraders. Cell Chem Biol. 2021;28(7):1032-1047. doi:10.1016/j.chembiol.2021.04.009

2020

Pathare GR, Decout A, Glück S, Cavadini S, Makasheva K, Hovius R, Kempf G, Weiss J, Kozicka Z, Guey B, Melenec P, Fierz B, Thomä NH, Ablasser A. Structural mechanism of cGAS inhibition by the nucleosome. Nature. 2020 Nov;587(7835):668-672. doi: 10.1038/s41586-020-2750-6.

Kassube SA, Thomä NH. Structural insights into Fe-S protein biogenesis by the CIA targeting complex.

Nat Struct Mol Biol. 2020 Aug;27(8):735-742. doi: 10.1038/s41594-020-0454-0.

Słabicki M, Kozicka Z, Petzold G, Li YD, Manojkumar M, Bunker RD, Donovan KA, Sievers QL, Koeppel J,

Michael AK*, Grand RS*, Isbel L*, Cavadini S, Kozicka Z, Kempf G, Bunker RD, Schenk AD, Graff-Meyer A, Pathare GR, Weiss J, Matsumoto S, Burger L, Schübeler D, Thomä NH. Mechanisms of OCT4-SOX2 motif readout on nucleosomes. Science. 2020 Jun 26;368(6498):1460-1465. doi: 10.1126/science.abb0074.

Schenk AD, Cavadini S, Thomä NH, Genoud C. ​Live Analysis and Reconstruction of Single-Particle Cryo-Electron Microscopy Data with CryoFLARE J Chem Inf Model​. 2020 May 26;60(5):2561-2569.

doi: 10.1021/acs.jcim.9b01102.

2019

Matsumoto S*, Cavadini S*, Bunker RD*, Grand RS, Potenza A, Rabl J, Yamamoto J, Schenk AD, Schübeler D, Iwai S, Sugasawa K, Kurumizaka H & Thomä NH (2019) DNA damage detection in nucleosomes involves DNA register shifting. Nature. Jul;571(7763):79-84.

​

​

2018

Sievers QL,* Petzold G*, Bunker RD, Renneville A, Slabicki M, Liddicoat BJ, Abdulrahman W, Mikkelsen T, Ebert BL, Thomä NH (2018) Defining the human C2H2 zinc finger degrome targeted by thalidomide analogs through CRBN. Science. Nov 2;362(6414)

Cannavo E, Johnson D, Andres SN, Kissling VM, Reinert JK, Garcia V, Erie DA, Hess D, Thomä NH, Enchev RI, Peter M, Williams RS, Neale MJ, Cejka P (2018) Regulatory control of DNA end resection by Sae2 phosphorylation. Nature Communications. Oct 1;9(1):4016

Fontana GA, Reinert JK, Thomä NH, Rass U. (2018) Shepherding DNA ends: Rif1 protects telomeres and chromosome breaks. Microb Cell. May 17;5(7):327-343

Ostapcuk V, Mohn F, Carl SH, Basters A, Hess D, Iesmantavicius V, Lampersberger L, Flemr M, Pandey A, Thomä NH, Betschinger J, Bühler M. (2018) Activity-dependent neuroprotective protein recruits HP1 and CHD4 to control lineage-specifying genes. Nature. May;557(7707):739-743.

2017

Mattarocci S, Reinert JK, Bunker RD, Fontana GA, Shi T, Klein D, Cavadini S, Faty M, Shyian M, Hafner L, Shore D, Thomä NH, Rass U. (2017) Rif1 maintains telomeres and mediates DNA repair by encasing DNA ends. Nature Structural & Molecular Biology Jul;24(7):588-595

Walczak MJ, Petzold G, Thomä NH (2017) Targeted protein degradation: You can glue it too! Nature Chemical Biology. Apr 13;13(5):452-453.

For full list of publications click here

@LabThoma

Michael AK, Grand RS, Isbel L*, Cavadini S, Kozicka Z, Kempf G, Bunker RD, Schenk AD, Graff-Meyer A, Pathare GR, Weiss J, Matsumoto S, Burger L, Schübeler D, Thomä NH. Mechanisms of OCT4-SOX2 motif readout on nucleosomes. Science. 2020 Jun 26;368(6498):1460-1465. doi: 10.1126/science.abb0074.

Schenk AD, Cavadini S, Thomä NH, Genoud C. Live Analysis and Reconstruction of Single-Particle Cryo-Electron Microscopy Data with CryoFLARE J Chem Inf Model. 2020 May 26;60(5):2561-2569.

Matsumoto S, Cavadini S, Bunker RD*, Grand RS, Potenza A, Rabl J, Yamamoto J, Schenk AD, Schübeler D, Iwai S, Sugasawa K, Kurumizaka H & Thomä NH (2019) DNA damage detection in nucleosomes involves DNA register shifting. Nature. Jul;571(7763):79-84.